REDUCED TYROSINE KINASE INHIBITOR DOSE IS PREDICTED TO BE AS EFFECTIVE AS STANDARD DOSE IN CHRONIC MYELOID LEUKEMIA: A SIMULATION STUDY BASED ON PHASE III TRIAL DATA

Continuing tyrosine kinase inhibitor (TKI)-mediated targeting of the BCR-ABL1 oncoprotein is the standard therapy for chronic myeloid leukemia (CML) and allows for a sustained disease control in the majority of patients.While therapy cessation for patients appeared as a safe option for about half of those patients with optimal response, no systemat

IL-17 is a cytokine produced by innate and acquired immunity cells that have an action against fungi and bacteria.However, its action in helminth infections is unclear, including in Toxocara canis infection.Toxocariasis is a neglected zoonosis representing a significant public health problem with an estimated seroprevalence of 19% worldwide.In the

The surface cracks on high-speed railway ballastless track slabs directly influence their lifespan, while the efficiency of damage detection and maintenance is crucial for ensuring operational safety.Leveraging deep learning image processing technology can significantly enhance detection efficiency.Therefore, in response to the specific attributes

When South Africa is covered in the Swedish media, the focus is often on the history of South Africa, the role of Sweden in the anti-apartheid movement and, in more recent years, the political and socio-economic landscape of post-apartheid South Africa, marked by increased wealth gaps, social unrest, and corruption.How South Africa is covered by fo

Abstract To solve the problem of air gap eccentric fault of traction motor, the fault characteristic frequency is close to the fundamental frequency, and the decomposed STRENGTHENING GEL frequency affects each other, which is easy to cause spectrum aliasing.A reconstruction of variational mode decomposition method is proposed (reconstructed variati